Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions
Scientists studied the clinical efficacy of green tea extracts (polyphenone E; poly E and (-)-epigallocatechin-3-gallate [EGCG]) administered in the form of an ointment or capsule in patients with human papillomavirus (HPV) infected cervical lesions became.
51 patients with cervical lesions (chronic cervicitis, mild dysplasia, moderate dysplasia and severe dysplasia) were divided into four groups compared to 39 untreated patients as controls.
Poly E ointment was applied locally to 27 patients twice a week. For oral administration, one 200 mg Poly E or EGCG capsule was taken orally daily for eight to 12 weeks.
In the study, 20 of 27 patients (74%) responded to Poly E ointment therapy. Six of eight patients on Poly-E ointment plus Poly-E capsule therapy (75%) responded and three of six patients (50%) on Poly-E capsule therapy responded. Six out of 10 patients (60%) receiving EGCG capsule therapy showed a response.
An overall response rate of 69% (35/51) was observed for treatment with green tea extracts (high in EGCG content) , compared to a response rate of 10% (4/39) for untreated controls (P<0.05) .
Thus, the data collected here demonstrated that green tea extracts in ointment and capsule form are effective for treating cervical lesions , suggesting that green tea extracts may be a potential therapeutic regimen for patients with HPV-infected cervical lesions .
- European journal of cancer prevention: the official journal of the European Cancer Prevention Organization (ECP) 12(5):383-90 https://europepmc.org/article/med/14512803